Winkler et al 2023 - mouse estrus single-cell data
Description
Atlas of the mouse female reproductive during cycling and ageing. Ovary, oviduct, uterus, cervix and vagina of C57BL/6 mice were sampled. Experimental timepoints were 3 months old mice across all four estrus phases, pregnant (decidualized) and aged (18 months, acyclic) mice. A total of 483,611 cells were sequenced using 10X Chromium Gene Expression technology.
Data exploration app:
https://cancerevolution.dkfz.de/estrus
Download links
scRNA-seq raw and processed data are available at:
- Arrayexpress (E-MTAB-11491, all sequencing data and expression count matrices)
- Biostudies (S-BSST852, processed data from diverse analyses)
Flow cytometry raw data together with the MIFlowCyt protocol are available at:
- Biostudies (S-BSST864)
Imaging raw and processed data are available at:
Code used in this study is available in github repository:
For additional requests and questions please contact Duncan Odom d.odom A-T dkfz-heidelberg.de or Angela Goncalves a.goncalves A-T dkfz-heidelberg.de.
Citation
Winkler I., Tolkachov A., Lammers F., Lacour P., Schneider N., Koch M.L., Panten J., Grünschläger F., Daugelaite K., Poth T., Haas S., Odom D.T., Goncalves A. (2023) The function and decline of the female reproductive tract at single-cell resolution. bioRxiv.